COX LAB
Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
Watson RO, Manzanillo PS, Cox JS.
Cell. 2012 Aug 17;150(4):803-15.
PubMed PMID: 22901810.
Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages
Manzanillo PS, Shiloh MU, Portnoy DA, Cox JS.
Cell Host Microbe. 2012 May 17;11(5):469-80.
PubMed PMID: 22607800.
Sulfolipid-1 biosynthesis restricts Mycobacterium tuberculosis growth in human macrophages
Gilmore SA, Schelle MW, Holsclaw CM, Leigh CD, Jain M, Cox JS, Leary JA, Bertozzi CR.
ACS Chem Biol. 2012 May 18;7(5):863-70.
PubMed PMID: 22360425
TB Lipidomics-The Final Frontier
Chow ED, Cox JS.
Chem Biol. 2011 Dec 23;18(12):1517-8. PubMed PMID: 22195552.
EspR, a key regulator of Mycobacterium tuberculosis virulence, adopts a unique dimeric structure among helix-turn-helix proteins
Oren S. Rosenberg, Cole Dovey, Michael Tempesta, Rebecca A. Robbins, Janet S. Finer-Moore, Robert Stroud, and Jeffery S. Cox
Proceedings of the National Academy of Sciences 108(33), 13450-13455 (2011)
PDF.
Mycobacterium tuberculosis MycP1 Protease Plays a Dual Role in Regulation of ESX-1 Secretion and Virulence
Yamini M. Ohol, David H. Goetz, Kaman Chan, Michael U. Shiloh, Charles S. Craik, and Jeffery S. Cox
Cell Host & Microbe 7, 210-220 (2010)
PDF.
Comprehensive Functional Analysis of Mycobacterium tuberculosis Toxin-Antitoxin Systems: Implications for Pathogenesis, Stress Responses, and Evolution
Holly R. Ramage, Lynn E. Connolly, and Jeffery S. Cox
PLoS Genetics 5(12), e1000767 (2009)
PDF.
ESX-1 Secreted Virulence Factors are Recognized by Multiple Cytosolic AAA ATPases in Pathogenic Mycobacteria
Patrcia A. DiGiuseppe Champion, Matthew M. Champion, Paolo Manzanillo, and Jeffery S. Cox
Molecular Microbiology 73(5), 950-962 (2009)
PDF.
CarD Tricks and Magic Spots: Mechanisms of Stringent Control in Mycobacteria
Lynn E. Connolly and Jeffery S. Cox
Cell Host & Microbe 6(1), 1-2 (2009)
PDF.
Secreted Transcription Factors Controls Mycobacterium tuberculosis Virulence
Sridharan Raghavan, Paolo Manzanillo, Kaman Chan, Cole Dovey, and Jeffery S. Cox
Nature 454(7205), 717-721 (2008)
PDF.
Commentary in Nature by Steven A. Porcelli (PDF)
Mycobacterium tuberculosis Senses Host-Derived Carbon Monoxide during Macrophage Infection
Michael U. Shiloh, Paolo Manzanillo, and Jeffery S. Cox
Cell Host & Microbe 3(5), 323-330 (2008)
PDF.
Commentary in Cell Host & Microbe by Photini Sinnis and Joel D. Ernst (PDF)
Protein Secretion Systems in Mycobacteria
Patrcia A. DiGiuseppe Champion and Jeffery S. Cox
Cellular Microbiology 9(6), 1376-1384 (2007)
PDF.
Lipidomics Reveals Control of Mycobacterium tuberculosis Virulence Lipids via Metabolic Coupling
Madhulika Jain, Christopher J. Petzold, Michael W. Schelle, Michael D. Leavell, Joseph D. Mougous, Carolyn R. Bertozzi, Julie A. Leary, and Jeffery S. Cox
Proceedings of the National Academy of Sciences 104(12), 5133-5138 (2007)
PDF.
A Genetic Screen for Mycobacterium tuberculosis Mutants Defective for Phagosome Maturation Arrest Identifies Components of the ESX-1 Secretaion System
Jason A. MacGurn and Jeffery S. Cox
Infection and Immunity 75(6), 2668-2678 (2007)
PDF.
The Type I IFN Response to Infection with Mycobacterium tuberculosis Requires ESX-1-Mediated Secretion and Contributes to Pathogenesis
Sarah A. Stanley, James E. Johndrow, Paolo Manzanillo, and Jeffery S. Cox
Journal of Immunology 178(5), 3143-3152 (2007)
PDF.
C-Terminal Signal Sequence Promotes Virulence Factor Secretion in Mycobacterium tuberculosis
Patrcia A. DiGiuseppe Champion, Sarah A. Stanley, Matthew M. Champion, Eric J. Brown, and Jeffery S. Cox
Science 313, 1632-1636 (2006)
PDF.
Commentary in Science by Berengere Ize and Tracy Palmer (PDF)
A Non-RD1 Gene Cluster is Required for Snm Secretion in Mycobacterium tuberculosis
Jason A. MacGurn, Sridharan Raghavan, Sarah A. Stanley, and Jeffery S. Cox
Molecular Microbiology 57(6), 1653-1663 (2005)
PDF.
Interaction between Polyketide Synthase and Transporter Suggests Coupled Synthesis and Export Virulence Lipid in M. tuberculosis
Madhulika Jain and Jeffery S. Cox
PLoS Pathogens 1(1), e2 (2005)
PDF.
A Protein Secretaion Pathway Critical for Mycobacterium tuberculosis Virulence Is Conserved and Functional in Mycobacterium smegmatis
Scott E. Converse and Jeffery S. Cox
Journal of Bacteriology 187(4), 1283-1245 (2005)
PDF.
Acute Infection and Macrophage Subversion by Mycobacterium tuberculosis Require a Specialized Secretion System
Sarah A. Stanley, Sridharan Raghavan, William W. Hwang, and Jeffery S. Cox
Proceedings of the National Academy of Sciences 100(22), 13001-13006 (2003)
PDF.
MmpL8 is Required for Sulfolipid-1 Biosynthesis and Mycobacterium tuberculosis Virulence
Scott E. Converse, Joseph D. Mougous, Michael D. Leavell, Julie A. Leary, Carolyn R. Bertozzi, and Jeffery S. Cox
Proceedings of the National Academy of Sciences 100(10), 6121-6126 (2003)
PDF.
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